I am not a windows expert, but a couple of questions/suggestions.

The number one is, are you running any plugins? And if you are, does the problem occur when you run with no plugins?

I presume you retried the save and the "permission denied" continued after you had checked that nobody had a handle on the file?

Are you using windows native dialogs or GTK dialogs? And does the problem occur when you try the other? I vaguely remember something about dialogs having locks on files or directories because they read the metadata to populate the dialog.

IIRC the gio_unsafe_save_backup needs use_gio_unsafe_file_saving set as well.

Does the problem occur if you have neither use_atomic_file_saving nor use_gio_unsafe_file_saving nor gio_unsafe_save_backup set?

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