At 300MB on a Linux box my Geany freezes up too. Have you considered breaking the file into smaller chunks for processing? E.g. The way syslog manages logs by creating sequenced files. If you need to keep that size and edit it every so often, I recommend you use an editor that can NOT load the whole file such as vi (hit Ctrl-C when it starts loading to cancel enumeration) - it's a powerful editor to learn anyway.

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